Breast cancer is the most common cancer in women. Scientists from Purdue University and the French Institute of Western Oncology (ICO) have discovered that glyphosate, the main constituent of some common herbicides and pesticides, can cause breast cancer in women. certain conditions. The new study comes at a time when it was announced that the next glyphosate treatment process in the United States was postponed. After three courts had sentenced BayerMonsanto in first instance to fines of one million, negotiated Bayer is negotiating with more than 18,000 plaintiffs about an amicable settlement. The new study is worrying because, according to scientists, this is not the most common type of breast cancer, but the most aggressive form that occurs in younger women, also called cancer of the canal. B of light.
Glyphosate and breast cancer
Glyphosate, along with another risk factor, can trigger aggressive breast cancer. A recently published study is further evidence of the growing evidence of the carcinogenic potential of glyphosate weed killer. Glyphosate herbicides such as Roundup are used in more than 85% of genetically modified crops.
No cancer by glyphosate – insists on the chemical manufacturer Bayer. Bayer had bought $ 63 billion from the US seed company and glyphosate maker Monsanto 2018 and is facing about 18,400 claims for alleged cancer risks from gyphosathaltiger herbicides. They went to court because the Roundup weed killer is supposed to cause cancer.
While Bayer is seeking a settlement with more than 18,000 plaintiffs in the United States, the next lawsuit is coming to Australia, she added. Gardener Michael Ogalirolo, 54, diagnosed with non-Hodgkin's lymphoma after more than 20 years of using Monsanto's Roundup, filed a lawsuit against Monsanto of Bayer AG, claiming his illness was due to glyphosate. The Cancer Council Australia is concerned that for more than two decades there has been no official or independent review of the chemical glyphosate – the drug contained in Roundup. See the lawsuit against BayerMonsanto for non-Hodgkin lymphoma in Australia! – First Roundup cancer trial against Weedkiller Roundup in Australia
Aggressive form of cancer due to glyphosate
Scientists from Purdue University and the French Institute of Western Oncology (ICO) have discovered that glyphosate, the main constituent of some common herbicides and pesticides, can cause breast cancer in women. certain conditions. This discovery is another step forward in determining cancer development and prevention.
Scientists know that the breast cancer prevention solution will not be easy, but a team of researchers from Purdue University and the National Institute of Health and Medical Research (INSERM) / Institute of Cancer Research 'West (ICO) in Nantes, France, says they've recently discovered one of the missing pieces of the puzzle in cancer prevention.
The Purdue Cancer Research Center, in collaboration with the ICO and the Cancer Center of Western France, as part of an agreement with the international initiative IBCN (Breast Cancer and Nutrition), found that glyphosate, the main constituent of widely used herbicides, may result in breast cancer if it is associated with another risk factor. The work was published in Frontiers in Genetics. "This is an important result that no one has shown yet," says Sophie Lelièvre, a professor of cancer pharmacology at Purdue College of Veterinary Medicine and co-director of IBCN.
"Demonstrating that glyphosate can trigger tumor growth when it is associated with another generally observed risk is an important missing link in determining the cause of cancer." Scientists used non-carcinogenic human milk epithelial cells in vitro 21-day period from glyphosate. The cells were then implanted in mice to evaluate the formation of tumors. Although cells exposed to glyphosate alone did not induce tumor growth, cancerous tumors developed after glyphosate was associated with molecules associated with oxidative stress. Oxidative stress is a chemical reaction that results from aging, diet, alcohol consumption, smoking, or other stressors. It alters the organization and integrity of the breast genome and promotes the development of cancer.
"What was particularly troubling in tumor growth, in particular, was that it was not the type of breast cancer we see in older women," said Lelièvre (… ). "It was the most aggressive form that occurs in younger women, also known as B-luminal cancer."
Glyphosate is the subject of a vast scientific debate in cancer research. United States The Environmental Protection Agency said in a risk assessment in 2017 that it was unlikely that the herbicide would be carcinogenic. However, in 2015, the International Agency for Research on Cancer of the World Health Organization declared that glyphosate was "probably carcinogenic". Research published in 2017 also linked glyphosate to non-Hodgkin's lymphoma.
Another important finding was the ability to identify the pathway at the epigenetic level (ie, chemical markers on DNA and the proteins controlling gene expression) used by glyphosate to compromise breast cells. . Lelièvre and Gwenola Bougras-Cartron, principal investigator of the ICO project, hope that these results will enable researchers to identify and reverse the risk of breast cancer associated with this combination of risk factors.
"There is a big gap in research that aims to understand why cancer occurs," Lelièvre said. "This discovery is new, largely because there is no scientific evidence so far that a second factor, when it is linked to common pollutants, is enough." to develop cancer.It is very difficult to identify the causes of breast cancer, but it is a crucial step in the right direction to start with prevention, as indicated in the collaboration. IBCN International (www.purdue.edu/breastcancer) ".
Cancer rates continue to increase worldwide, with breast cancer being the most prevalent form, said Cancer.gov. Lelièvre said that these facts alone fuel the motivation of his research, hoping to find a way to prevent cancer even before it starts.
"The research was about both treatment and detection, but prevention is just not as common," Lelièvre said. "If we can find a way to minimize the risks, we can expect fewer cases."
The work was funded by the National League Against Cancer in France.
Lelièvre is an advocate of advanced cell culture models that mimic different stages of cancer development for research. She collaborated with a Purdue research team to develop and contribute to a device sponsored by the Congressionally-mandated Medical Research Program / Breast Cancer Research Program. identify the risk factors and mechanisms underlying the origin of breast cancer. She is also working with researchers to create tumor models in 10 days more appropriate for those of the human body to test new treatments and seek drug sensitivity.
This work fits into the giant steps of Purdue, which celebrate the advancement of the University's global health as part of Purdue's 150th anniversary. It is one of four themes of the Festival of Ideas of the One Year Celebration, designed to present Purdue as an intellectual center for real problem solving.
GMWatch (@GMWatch) October 1, 2019
Pesticides and breast cancer
By Abbey Nickel
Can herbicides cause breast cancer? Purdue and INSERM scientists discover a piece of the puzzle.
Scientists from Purdue University and the French Institute of Western Cancer (ICO) have discovered that glyphosate, the main ingredient of some widely used herbicides and pesticides, can cause breast cancer under certain conditions. When it comes to determining how cancer starts and how to prevent it.
Scientists know that the solution is found at Purdue University and at the National Institute of Health and Medical Research (INSERM) / Western Cancer Institute (ICO) In Nantes, France, they come from discover one of the missing pieces of the puzzle in cancer prevention.
The Purdue Cancer Research Center, in collaboration with ICO, the Cancer Center of Western France, under a protocol agreement with the international initiative IBCN (Breast Cancer and Nutrition) led by Purdue, discovered that glyphosate, the main ingredient of widespread herbicides can lead to breast cancer when it is associated with another risk factor. The work was published in Frontiers in Genetics.
Sophie Lelièvre, professor of cancer pharmacology at Purdue College of Veterinary Medicine and co-director of IBCN. "Demonstrating that glyphosate can trigger tumor growth, when it is associated with another major risk factor, is an important missing link."
Scientists exposed non-cancerous human mammary epithelial cells to glyphosate in vitro for 21 days. The cells were then placed on mice to evaluate tumor formation. Although cells exposed to glyphosate are not linked to oxidative stress. Oxidative stress is the result of aging, diet, alcohol consumption, smoking or other stressors, as well as aging of the breast genome, thus promoting the development of cancer.
Lelièvre (pronounced LE-LEE-YEA-vre) said: "What is particularly alarming about tumor growth? "It was the most aggressive form in younger women, called B-light cancer."
Glyphosate has been the subject of many scientific debates on cancer research. The United States Environmental Protection Agency said in a 2017 risk assessment that the herbicide was probably not carcinogenic. However, in 2015, the International Agency for Research on Cancer of the World Health Organization declared that glyphosate was "probably carcinogenic". A research published in 2017, namely a glyphosate associated with non-Hodgkin's lymphoma.
Another key finding of researchers at the epigenetic level (ie the chemical markings on DNA and the proteins that control gene expression), used by glyphosate to endanger breast cells. Lelièvre and Gwenola Bougras-Cartron, senior scientist of the ICO project, hope this evidence will enable researchers to detect and reverse the risk of breast cancer associated with this combination of risk factors.
Lelièvre said: "There is a huge gap in the research that is developing." This discovery is new, it has not been proven by scientific evidence that it has a second factor. In the international collaborative work of IBCN (http://www.purdue.edu/breastcancer), it is very difficult to determine the cause of breast cancer, but it is a decisive step in the right direction. "
The incidence of cancer continues to increase worldwide, with breast cancer being the most prevalent type, according to Cancer.gov. Lelièvre said the facts continue to fuel research for the future.
"Research for both treatment and detection has been given special attention, but prevention is not widespread," said Lelièvre. "If we can find a way to mitigate the risks, we can expect fewer cases."
The work was funded by the National League Against Cancer in France.
Lelièvre is a leading researcher on cell culture who has worked in the field of cancer research at the University of California. Breast Cancer Research Program / Program, which aims to identify the risk factors for cancer and the underlying cancer. She works with researchers to create tumor models.
This work aligns with the celebration of the world's advances in health education as part of Purdue's 150th anniversary. This is one of the four themes of the year-long Ideas Festival, designed to introduce Purdue as an intellectual center solving real-world problems.
Glyphosate prepares mammary cells for tumorigenesis by reprogramming the epigenome in a TET3-dependent manner
Manon Duforestel, Arulaj Nadaradjane, Gwenola Bougras-Cartron, Joséphine Briand, Christophe Olivier, Jean-Sebastien Frenel, Francois M Vallette, Sophie A. Lelièvre, Pierre-François Cartron
Frontiers in Genetics, September 27, 2019
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