(At the time, Juul, the best-selling product in the US, was not available in England.) Juul's nicotine levels are much higher, either 59 milligrams or 35 milligrams.)

All participants had individual flexibility within their study groups to get close to actual scenarios. When vapers have finished their liquid nicotine bottle, they can choose the aroma and strength of nicotine to buy.

People using nicotine replacement therapy could choose from a wide range of products, including patch, gum, lozenge and nasal spray. They were even encouraged to combine them; most have done so, generally opting for the patch and oral therapy.

Since self-reports of smoking abstinence were not considered reliable, the researchers measured the amounts of carbon monoxide present in the participants' breath, which is a more accurate validation.

Dr. Maciej Goniewicz, co-author of the British study, pharmacologist at Roswell Park Comprehensive Cancer Center in Buffalo, NJ, said the success of e-cigarettes most likely reflected a combination of factors:

"It's the method of delivery, the amount of nicotine and the behavior of the user," he said. "E-cigarettes have the advantage of allowing the user to decide how and when to inflate. Nicotine replacement therapy products have specific instructions, which are different for different products. "

Dr. Benowitz noted that smoking cessation rates and compliance among users of e-cigarettes could also be explained because these subjects were more satisfied with devices than other groups with their products.

In their editorial, Drs. Borrelli and O'Connor reported on other research on smoking cessation: In one study, nicotine replacement therapy and the buproprion antidepressant (Wellbutrin) had a slightly higher abstinence rate than e-cigarettes. last test. Varenicline (Chantix), a prescription drug, has achieved even better results. In addition, these products have been proven safe, they said.